Microwave Assisted Synthesis of Pyrano [2, 3-d] Pyrimidinone Derivatives
نویسندگان
چکیده
The parent barbituric acid and 2-thiobarbituric acid are convenient starting compounds for the preparation of different fused heterocycles and 5-substituted derivatives which are pharmacologically one of the most important classes of barbituric acid based compounds. The fused compounds of barbituric and thiobarbituric acid 7-(4-aminophenyl)-5-aryl5H-pyrano [2, 3-d] pyrimidinone, 5a-f have been synthesized in single step by the condensation of barbituric acid/thiobarbituric acid with benzylidene/ substituted benzylidene acetophenone in glacial acetic acid in the presence of phosphorous pentoxide under microwave irradiation. The structures of the compounds were characterized by their UV, IR, H NMR and C NMR spectral data. Index Term-barbituric acid, 2-thiobarbituric acid, microwave irradiation, fused heterocycle.I.
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